Ah, D-dimers, the exposed crosslink fragments resulting from the cleaving of fibrin mesh by plasmin. They predict everything – and nothing, with poor positive likelihood ratios for scads of pathologic diagnoses, and limited negative likelihood ratios for others.  Little wonder, then, routine D-dimer assays were part of the PESIT trial taking the diagnosis of syncope … Continue reading Is The Road to Hell Paved With D-Dimers?