{"id":1249,"date":"2011-10-10T10:00:00","date_gmt":"2011-10-10T10:00:00","guid":{"rendered":"http:\/\/www.emlitofnote.com\/?p=1249"},"modified":"2016-08-01T08:59:00","modified_gmt":"2016-08-01T15:59:00","slug":"600mg-is-probably-your-best-clopidogrel-loading-dose-2","status":"publish","type":"post","link":"https:\/\/www.emlitofnote.com\/?p=1249","title":{"rendered":"600mg Is Probably Your Best Clopidogrel Loading Dose"},"content":{"rendered":"<div>Most STEMI is the result of an acute thrombotic event, so, more thrombotic inhibition is better, right?&nbsp; Italy, Hungary, Serbia and Belgium band together for ARMYDA-6 to test a randomized, prospective 600mg vs. 300mg clopidogrel loading dose prior to PCI in STEMI.<\/div>\n<div><\/div>\n<div>They didn&#8217;t look at mortality and only followed 30-day outcomes &#8211; probably because they didn&#8217;t have statistical power from only 201 patients to detect a difference &#8211; but their surrogate markers of infarct size, successful PCI, LVEF and 30-day &#8220;major cardiovascular events&#8221; all favored clopidogrel.&nbsp; Unfortunately, almost every nonsignificant difference between the two clinical groups favored the 600mg group &#8211; younger, less diabetes, fewer prior MIs, higher LVEF at baseline, faster loading and cath lab times, less multivessel disease, more TIMI flow &gt;1 pre-PCI.<\/div>\n<div><\/div>\n<div>That being said, it&#8217;s consistent with the prior ARMYDA-1 and CURRENT-OASIS studies, and even if this isn&#8217;t a fabulous study, it&#8217;s another but of evidence to consider.<\/div>\n<div><\/div>\n<div>&#8220;Outcome Comparison of 600- and 300-mg Loading Doses of Clopidogrel in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segement Elevation Myocardial Infarction&#8221;<\/div>\n<div><a href=\"http:\/\/content.onlinejacc.org\/cgi\/content\/full\/58\/15\/1592\">content.onlinejacc.org\/cgi\/content\/full\/58\/15\/1592<\/a><\/div>\n\n<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?via=emlitofnote\" class=\"twitter-share-button\">Tweet<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Most STEMI is the result of an acute thrombotic event, so, more thrombotic inhibition is better, right?&nbsp; Italy, Hungary, Serbia and Belgium band together for ARMYDA-6 to test a randomized, prospective 600mg vs. 300mg clopidogrel loading dose prior to PCI in STEMI. They didn&#8217;t look at mortality and only followed 30-day outcomes &#8211; probably because &hellip; <a href=\"https:\/\/www.emlitofnote.com\/?p=1249\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;600mg Is Probably Your Best Clopidogrel Loading Dose&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[6],"tags":[],"class_list":["post-1249","post","type-post","status-publish","format-standard","hentry","category-cardiology"],"jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7KesJ-k9","jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/1249","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1249"}],"version-history":[{"count":1,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/1249\/revisions"}],"predecessor-version":[{"id":2965,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/1249\/revisions\/2965"}],"wp:attachment":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1249"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1249"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1249"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}