{"id":4413,"date":"2019-03-21T21:29:25","date_gmt":"2019-03-22T04:29:25","guid":{"rendered":"http:\/\/www.emlitofnote.com\/?p=4413"},"modified":"2019-03-21T21:29:30","modified_gmt":"2019-03-22T04:29:30","slug":"emergencies-in-medicine","status":"publish","type":"post","link":"https:\/\/www.emlitofnote.com\/?p=4413","title":{"rendered":"Emergencies in Medicine"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Just a quick note to follow-up this <a href=\"http:\/\/emergenciesinmedicine.org\">splendid little conference<\/a> in Park City, UT, where I featured in a debate regarding the utility of tPA for stroke.  We had a generally respectful discussion about the state of stroke care and our vision for the future.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Unfortunately, it \u2013 as you might expect \u2013 looks a lot like a future where tPA flows like water.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The overall gist of the presentation by Chris Lewandowski, one of the original NINDS investigators: pool the trial data, and the benefit is clear.  My gripes, well-chronicled on this site: benefit is not uniformly distributed, we should tailor its use, rather than expand it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Interesting tidbits from the follow-up discussion:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li> No one is going to re-do NINDS in this country.  They couldn&#8217;t even complete <a href=\"https:\/\/www.emlitofnote.com\/?p=4235\">PRISMS<\/a> because too many mild, non-disabling strokes were already being treated.<\/li><li> Treating vast numbers of stroke mimics is not troublesome to them \u2013 Lewandowski claims to have never heard of one ever having a bleed.<\/li><li> The expected benefit to mobile stroke units relates to &#8220;fresh&#8221; clot being more likely to lyse, as much as the brief time savings.<\/li><li> Studies like <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03181360\">TIMELESS<\/a> and other tissue-based thrombolytic studies will likely extend the treatment window, just like <a href=\"https:\/\/www.emlitofnote.com\/?p=4198\">WAKE-UP<\/a>.<\/li><li> No qualms about treating NIHSS scores of 1 causing only mild disability (say, unilateral leg weakness).  They&#8217;ve seen that some NIHSS 1 deteriorate, and believe tPA will prevent it.<\/li><li> They are utterly comfortable with forever using NINDS as their default NNT\/NNH consent \u2013\u00a0and no problem using the same numbers now matter what the NIHSS.  Except, they just reduce their risk number for harm, as ICH is generally related to infarct size\/NIHSS.  This drives me mad.<\/li><li> They feel strongly tPA has been proven &#8220;cost-effective&#8221;, while I would note those analyses are based on assumptions and models not matching current practice and treatment population.<\/li><li> Treating cervical artery dissection with tPA is favored to them because they expect the clot that showers distally will benefit from lysis, though they agree there is no evidence to support their claims.<\/li><li> They agreed that, overall, the recommendations issued by the AHA overstate the strength of the evidence.<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Would be fun to do again \u2013 even if it is effectively just shouting into the wind!<\/p>\n\n<div class=\"twitter-share\"><a href=\"https:\/\/twitter.com\/intent\/tweet?via=emlitofnote\" class=\"twitter-share-button\">Tweet<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Just a quick note to follow-up this splendid little conference in Park City, UT, where I featured in a debate regarding the utility of tPA for stroke. We had a generally respectful discussion about the state of stroke care and our vision for the future. Unfortunately, it \u2013 as you might expect \u2013 looks a &hellip; <a href=\"https:\/\/www.emlitofnote.com\/?p=4413\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Emergencies in Medicine&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"nf_dc_page":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"Just a quick flashback to the #stroke debate I had in Park City a couple weeks ago ....","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[14,15],"tags":[],"class_list":["post-4413","post","type-post","status-publish","format-standard","hentry","category-neurology","category-stroke"],"jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7KesJ-19b","jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/4413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4413"}],"version-history":[{"count":1,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/4413\/revisions"}],"predecessor-version":[{"id":4414,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=\/wp\/v2\/posts\/4413\/revisions\/4414"}],"wp:attachment":[{"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emlitofnote.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}