From China, in Stroke, an animal model (poor rats, as usual) of MCA ischemia, collagenase-induced ICH, and post-TPA ICH. Rats received either 0.5 mg/kg, 1.0 mg/kg, or 1.5 mg/kg ethanol after two hours of MCA occlusion. Performance on various foot, balance, and parallel behavioral testing significantly favored the ethanol treatment group with initial and sustained reduction in errors as compared to the no-treatment group.
No difference was found between groups in induced ICH volume, and in their (small) series, no increase in ICH after TPA administration. A transient increase in expression of hypoxia-inducible factor 1-alpha favoring ethanol was seen at 3 hours after reperfusion, gone by 24 hours.
I cannot wait to see the day where we give IV ethanol for acute stroke.
“Beer, the cause and solution to all the world’s problems.”
“Neuroprotective Effect of Acute Ethanol Administration in a Rat With Transient Cerebral Ischemia”